| 1 | DreamsDreams5–2 Great OlympicsGreat Olympics | 3 | 7 | 20 Mar 2022 |
| 1 | Bibiani Gold StarsBibiani Gold Stars3–4 WAFAWest African Football Academy | 1 | 7 | 5 Jun 2022 |
| 3 | Ashanti GoldAshanti Gold6–0 WAFAWest African Football Academy | 6 | 6 | 9 Apr 2022 |
| 3 | Aduana StarsAduana Stars5–1 RTUReal Tamale United | 4 | 6 | 21 Nov 2021 |
| 3 | Ashanti GoldAshanti Gold5–1 Berekum ChelseaBerekum Chelsea | 4 | 6 | 1 May 2022 |
| 3 | KarelaKarela5–1 RTUReal Tamale United | 4 | 6 | 5 Jun 2022 |
| 3 | KarelaKarela4–2 Eleven WondersEleven Wonders | 2 | 6 | 2 Jan 2022 |
| 3 | Great OlympicsGreat Olympics3–3 DreamsDreams | 0 | 6 | 21 Nov 2021 |
| 9 | Asante KotokoAsante Kotoko5–0 Bibiani Gold StarsBibiani Gold Stars | 5 | 5 | 13 Mar 2022 |
| 9 | Hearts of OakHearts of Oak4–1 Eleven WondersEleven Wonders | 3 | 5 | 16 Jan 2022 |
| 9 | Ashanti GoldAshanti Gold1–4 Eleven WondersEleven Wonders | 3 | 5 | 27 Feb 2022 |
| 9 | Hearts of OakHearts of Oak1–4 RTUReal Tamale United | 3 | 5 | 19 Jun 2022 |
| 9 | Legon CitiesLegon Cities3–2 RTUReal Tamale United | 1 | 5 | 6 Nov 2021 |
| 9 | Asante KotokoAsante Kotoko2–3 King FaisalKing Faisal | 1 | 5 | 5 Dec 2021 |
| 9 | Aduana StarsAduana Stars3–2 Berekum ChelseaBerekum Chelsea | 1 | 5 | 19 Dec 2021 |
| 9 | King FaisalKing Faisal3–2 DreamsDreams | 1 | 5 | 21 Dec 2021 |
| 9 | Elmina SharksElmina Sharks2–3 Bechem UnitedBechem United | 1 | 5 | 13 Mar 2022 |
| 9 | RTUReal Tamale United3–2 Berekum ChelseaBerekum Chelsea | 1 | 5 | 4 Apr 2022 |
| 9 | Eleven WondersEleven Wonders3–2 Bechem UnitedBechem United | 1 | 5 | 17 Apr 2022 |
| 9 | WAFAWest African Football Academy3–2 Berekum ChelseaBerekum Chelsea | 1 | 5 | 17 Apr 2022 |
| 21 | Bechem UnitedBechem United4–0 MedeamaMedeama | 4 | 4 | 31 Oct 2021 |
| 21 | Ashanti GoldAshanti Gold4–0 Elmina SharksElmina Sharks | 4 | 4 | 16 Jan 2022 |
| 21 | Ashanti GoldAshanti Gold4–0 RTUReal Tamale United | 4 | 4 | 30 Mar 2022 |
| 21 | DreamsDreams1–3 Asante KotokoAsante Kotoko | 2 | 4 | 30 Oct 2021 |
| 21 | Aduana StarsAduana Stars1–3 King FaisalKing Faisal | 2 | 4 | 7 Nov 2021 |
| 21 | Elmina SharksElmina Sharks1–3 DreamsDreams | 2 | 4 | 7 Nov 2021 |
| 21 | Great OlympicsGreat Olympics3–1 Accra LionsAccra Lions | 2 | 4 | 7 Nov 2021 |
| 21 | DreamsDreams3–1 Accra LionsAccra Lions | 2 | 4 | 13 Nov 2021 |
| 21 | Eleven WondersEleven Wonders3–1 Elmina SharksElmina Sharks | 2 | 4 | 28 Nov 2021 |
| 21 | Bechem UnitedBechem United3–1 DreamsDreams | 2 | 4 | 28 Nov 2021 |
| 21 | DreamsDreams3–1 KarelaKarela | 2 | 4 | 15 Dec 2021 |
| 21 | Bibiani Gold StarsBibiani Gold Stars3–1 KarelaKarela | 2 | 4 | 26 Dec 2021 |
| 21 | Asante KotokoAsante Kotoko3–1 Ashanti GoldAshanti Gold | 2 | 4 | 9 Jan 2022 |
| 21 | DreamsDreams3–1 Aduana StarsAduana Stars | 2 | 4 | 24 Jan 2022 |
| 21 | Berekum ChelseaBerekum Chelsea3–1 Accra LionsAccra Lions | 2 | 4 | 30 Jan 2022 |
| 21 | Asante KotokoAsante Kotoko3–1 Accra LionsAccra Lions | 2 | 4 | 12 Feb 2022 |
| 21 | KarelaKarela3–1 Elmina SharksElmina Sharks | 2 | 4 | 3 Apr 2022 |
| 21 | Legon CitiesLegon Cities3–1 MedeamaMedeama | 2 | 4 | 17 Apr 2022 |
| 21 | Asante KotokoAsante Kotoko1–3 Legon CitiesLegon Cities | 2 | 4 | 24 Apr 2022 |
| 21 | Hearts of OakHearts of Oak3–1 DreamsDreams | 2 | 4 | 1 May 2022 |
| 21 | Elmina SharksElmina Sharks1–3 Ashanti GoldAshanti Gold | 2 | 4 | 22 May 2022 |
| 21 | Elmina SharksElmina Sharks1–3 MedeamaMedeama | 2 | 4 | 5 Jun 2022 |
| 21 | WAFAWest African Football Academy2–2 Legon CitiesLegon Cities | 0 | 4 | 21 Nov 2021 |
| 21 | DreamsDreams2–2 Hearts of OakHearts of Oak | 0 | 4 | 25 Dec 2021 |
| 21 | RTUReal Tamale United2–2 DreamsDreams | 0 | 4 | 2 Jan 2022 |
| 21 | Ashanti GoldAshanti Gold2–2 Bibiani Gold StarsBibiani Gold Stars | 0 | 4 | 13 Feb 2022 |
| 21 | Great OlympicsGreat Olympics2–2 WAFAWest African Football Academy | 0 | 4 | 30 Mar 2022 |
| 21 | King FaisalKing Faisal2–2 Bechem UnitedBechem United | 0 | 4 | 1 May 2022 |
| 21 | DreamsDreams2–2 RTUReal Tamale United | 0 | 4 | 8 May 2022 |
| 21 | Elmina SharksElmina Sharks2–2 WAFAWest African Football Academy | 0 | 4 | 8 May 2022 |