| 1 | WAFAWest African Football Academy5–4 MedeamaMedeama | 1 | 9 | 3 Jan 2021 |
| 2 | Ashanti GoldAshanti Gold7–0 Inter AlliesInter Allies | 7 | 7 | 17 Jul 2021 |
| 2 | Hearts of OakHearts of Oak6–1 Bechem UnitedBechem United | 5 | 7 | 2 Jan 2021 |
| 2 | Legon CitiesLegon Cities5–2 Ashanti GoldAshanti Gold | 3 | 7 | 22 Jan 2021 |
| 2 | WAFAWest African Football Academy4–3 King FaisalKing Faisal | 1 | 7 | 15 Nov 2020 |
| 2 | King FaisalKing Faisal4–3 Berekum ChelseaBerekum Chelsea | 1 | 7 | 30 Jan 2021 |
| 7 | Ashanti GoldAshanti Gold5–1 King FaisalKing Faisal | 4 | 6 | 16 Dec 2020 |
| 7 | Liberty ProfessionalsLiberty Professionals1–5 Ashanti GoldAshanti Gold | 4 | 6 | 24 Jun 2021 |
| 7 | Ashanti GoldAshanti Gold4–2 Elmina SharksElmina Sharks | 2 | 6 | 13 Dec 2020 |
| 7 | DreamsDreams4–2 Aduana StarsAduana Stars | 2 | 6 | 14 Feb 2021 |
| 7 | Inter AlliesInter Allies2–4 Aduana StarsAduana Stars | 2 | 6 | 11 Jul 2021 |
| 12 | WAFAWest African Football Academy5–0 Liberty ProfessionalsLiberty Professionals | 5 | 5 | 31 Jan 2021 |
| 12 | Inter AlliesInter Allies5–0 Berekum ChelseaBerekum Chelsea | 5 | 5 | 16 May 2021 |
| 12 | Berekum ChelseaBerekum Chelsea5–0 King FaisalKing Faisal | 5 | 5 | 6 Jun 2021 |
| 12 | KarelaKarela4–1 Berekum ChelseaBerekum Chelsea | 3 | 5 | 17 Jan 2021 |
| 12 | DreamsDreams4–1 Liberty ProfessionalsLiberty Professionals | 3 | 5 | 24 Jan 2021 |
| 12 | DreamsDreams4–1 Ashanti GoldAshanti Gold | 3 | 5 | 25 Feb 2021 |
| 12 | Ebusua DwarfsEbusua Dwarfs4–1 Great OlympicsGreat Olympics | 3 | 5 | 24 Apr 2021 |
| 12 | KarelaKarela1–4 Ebusua DwarfsEbusua Dwarfs | 3 | 5 | 28 Jun 2021 |
| 12 | Hearts of OakHearts of Oak3–2 Ebusua DwarfsEbusua Dwarfs | 1 | 5 | 21 Feb 2021 |
| 12 | Berekum ChelseaBerekum Chelsea2–3 WAFAWest African Football Academy | 1 | 5 | 30 Apr 2021 |
| 12 | WAFAWest African Football Academy2–3 Great OlympicsGreat Olympics | 1 | 5 | 7 May 2021 |
| 12 | Great OlympicsGreat Olympics2–3 Aduana StarsAduana Stars | 1 | 5 | 13 May 2021 |
| 12 | Liberty ProfessionalsLiberty Professionals3–2 WAFAWest African Football Academy | 1 | 5 | 6 Jun 2021 |
| 12 | Inter AlliesInter Allies2–3 Asante KotokoAsante Kotoko | 1 | 5 | 14 Jun 2021 |
| 12 | WAFAWest African Football Academy3–2 Aduana StarsAduana Stars | 1 | 5 | 23 Jun 2021 |
| 12 | MedeamaMedeama3–2 Elmina SharksElmina Sharks | 1 | 5 | 4 Jul 2021 |
| 12 | Liberty ProfessionalsLiberty Professionals3–2 KarelaKarela | 1 | 5 | 4 Jul 2021 |
| 12 | Legon CitiesLegon Cities3–2 Eleven WondersEleven Wonders | 1 | 5 | 18 Jul 2021 |
| 30 | Ashanti GoldAshanti Gold4–0 Aduana StarsAduana Stars | 4 | 4 | 19 Feb 2021 |
| 30 | Hearts of OakHearts of Oak4–0 WAFAWest African Football Academy | 4 | 4 | 7 Mar 2021 |
| 30 | Asante KotokoAsante Kotoko4–0 Bechem UnitedBechem United | 4 | 4 | 7 Apr 2021 |
| 30 | Liberty ProfessionalsLiberty Professionals4–0 Elmina SharksElmina Sharks | 4 | 4 | 10 Apr 2021 |
| 30 | Bechem UnitedBechem United4–0 Aduana StarsAduana Stars | 4 | 4 | 18 Apr 2021 |
| 30 | Ashanti GoldAshanti Gold4–0 Bechem UnitedBechem United | 4 | 4 | 25 Apr 2021 |
| 30 | KarelaKarela3–1 Elmina SharksElmina Sharks | 2 | 4 | 3 Jan 2021 |
| 30 | Eleven WondersEleven Wonders3–1 KarelaKarela | 2 | 4 | 10 Jan 2021 |
| 30 | Bechem UnitedBechem United3–1 Eleven WondersEleven Wonders | 2 | 4 | 29 Jan 2021 |
| 30 | Great OlympicsGreat Olympics3–1 King FaisalKing Faisal | 2 | 4 | 2 Feb 2021 |
| 30 | Bechem UnitedBechem United3–1 Great OlympicsGreat Olympics | 2 | 4 | 7 Feb 2021 |
| 30 | WAFAWest African Football Academy3–1 KarelaKarela | 2 | 4 | 24 Feb 2021 |
| 30 | Aduana StarsAduana Stars3–1 King FaisalKing Faisal | 2 | 4 | 11 Apr 2021 |
| 30 | Asante KotokoAsante Kotoko3–1 DreamsDreams | 2 | 4 | 8 May 2021 |
| 30 | Berekum ChelseaBerekum Chelsea3–1 Ashanti GoldAshanti Gold | 2 | 4 | 12 May 2021 |
| 30 | King FaisalKing Faisal3–1 Bechem UnitedBechem United | 2 | 4 | 16 May 2021 |
| 30 | Eleven WondersEleven Wonders3–1 Berekum ChelseaBerekum Chelsea | 2 | 4 | 26 Jun 2021 |
| 30 | Eleven WondersEleven Wonders3–1 MedeamaMedeama | 2 | 4 | 11 Jul 2021 |
| 30 | Ashanti GoldAshanti Gold2–2 KarelaKarela | 0 | 4 | 15 Nov 2020 |
| 30 | Ebusua DwarfsEbusua Dwarfs2–2 Elmina SharksElmina Sharks | 0 | 4 | 15 Nov 2020 |
| 30 | Hearts of OakHearts of Oak2–2 Ashanti GoldAshanti Gold | 0 | 4 | 24 Nov 2020 |