| 1 | Ashanti GoldAshanti Gold7–0 Inter AlliesInter Allies | 7 | 7 | 17 Jul 2021 |
| 2 | Hearts of OakHearts of Oak6–1 Bechem UnitedBechem United | 5 | 7 | 2 Jan 2021 |
| 2 | WAFAWest African Football Academy5–0 Liberty ProfessionalsLiberty Professionals | 5 | 5 | 31 Jan 2021 |
| 2 | Inter AlliesInter Allies5–0 Berekum ChelseaBerekum Chelsea | 5 | 5 | 16 May 2021 |
| 2 | Berekum ChelseaBerekum Chelsea5–0 King FaisalKing Faisal | 5 | 5 | 6 Jun 2021 |
| 6 | Ashanti GoldAshanti Gold5–1 King FaisalKing Faisal | 4 | 6 | 16 Dec 2020 |
| 6 | Liberty ProfessionalsLiberty Professionals1–5 Ashanti GoldAshanti Gold | 4 | 6 | 24 Jun 2021 |
| 6 | Ashanti GoldAshanti Gold4–0 Aduana StarsAduana Stars | 4 | 4 | 19 Feb 2021 |
| 6 | Hearts of OakHearts of Oak4–0 WAFAWest African Football Academy | 4 | 4 | 7 Mar 2021 |
| 6 | Asante KotokoAsante Kotoko4–0 Bechem UnitedBechem United | 4 | 4 | 7 Apr 2021 |
| 6 | Liberty ProfessionalsLiberty Professionals4–0 Elmina SharksElmina Sharks | 4 | 4 | 10 Apr 2021 |
| 6 | Bechem UnitedBechem United4–0 Aduana StarsAduana Stars | 4 | 4 | 18 Apr 2021 |
| 6 | Ashanti GoldAshanti Gold4–0 Bechem UnitedBechem United | 4 | 4 | 25 Apr 2021 |
| 14 | Legon CitiesLegon Cities5–2 Ashanti GoldAshanti Gold | 3 | 7 | 22 Jan 2021 |
| 14 | KarelaKarela4–1 Berekum ChelseaBerekum Chelsea | 3 | 5 | 17 Jan 2021 |
| 14 | DreamsDreams4–1 Liberty ProfessionalsLiberty Professionals | 3 | 5 | 24 Jan 2021 |
| 14 | DreamsDreams4–1 Ashanti GoldAshanti Gold | 3 | 5 | 25 Feb 2021 |
| 14 | Ebusua DwarfsEbusua Dwarfs4–1 Great OlympicsGreat Olympics | 3 | 5 | 24 Apr 2021 |
| 14 | KarelaKarela1–4 Ebusua DwarfsEbusua Dwarfs | 3 | 5 | 28 Jun 2021 |
| 14 | Great OlympicsGreat Olympics3–0 Legon CitiesLegon Cities | 3 | 3 | 20 Nov 2020 |
| 14 | Hearts of OakHearts of Oak3–0 DreamsDreams | 3 | 3 | 13 Dec 2020 |
| 14 | DreamsDreams3–0 WAFAWest African Football Academy | 3 | 3 | 3 Feb 2021 |
| 14 | MedeamaMedeama3–0 Ebusua DwarfsEbusua Dwarfs | 3 | 3 | 2 May 2021 |
| 14 | Ebusua DwarfsEbusua Dwarfs0–3 Legon CitiesLegon Cities | 3 | 3 | 9 May 2021 |
| 14 | DreamsDreams3–0 King FaisalKing Faisal | 3 | 3 | 12 May 2021 |
| 14 | Inter AlliesInter Allies3–0 MedeamaMedeama | 3 | 3 | 30 May 2021 |
| 27 | Ashanti GoldAshanti Gold4–2 Elmina SharksElmina Sharks | 2 | 6 | 13 Dec 2020 |
| 27 | DreamsDreams4–2 Aduana StarsAduana Stars | 2 | 6 | 14 Feb 2021 |
| 27 | Inter AlliesInter Allies2–4 Aduana StarsAduana Stars | 2 | 6 | 11 Jul 2021 |
| 27 | KarelaKarela3–1 Elmina SharksElmina Sharks | 2 | 4 | 3 Jan 2021 |
| 27 | Eleven WondersEleven Wonders3–1 KarelaKarela | 2 | 4 | 10 Jan 2021 |
| 27 | Bechem UnitedBechem United3–1 Eleven WondersEleven Wonders | 2 | 4 | 29 Jan 2021 |
| 27 | Great OlympicsGreat Olympics3–1 King FaisalKing Faisal | 2 | 4 | 2 Feb 2021 |
| 27 | Bechem UnitedBechem United3–1 Great OlympicsGreat Olympics | 2 | 4 | 7 Feb 2021 |
| 27 | WAFAWest African Football Academy3–1 KarelaKarela | 2 | 4 | 24 Feb 2021 |
| 27 | Aduana StarsAduana Stars3–1 King FaisalKing Faisal | 2 | 4 | 11 Apr 2021 |
| 27 | Asante KotokoAsante Kotoko3–1 DreamsDreams | 2 | 4 | 8 May 2021 |
| 27 | Berekum ChelseaBerekum Chelsea3–1 Ashanti GoldAshanti Gold | 2 | 4 | 12 May 2021 |
| 27 | King FaisalKing Faisal3–1 Bechem UnitedBechem United | 2 | 4 | 16 May 2021 |
| 27 | Eleven WondersEleven Wonders3–1 Berekum ChelseaBerekum Chelsea | 2 | 4 | 26 Jun 2021 |
| 27 | Eleven WondersEleven Wonders3–1 MedeamaMedeama | 2 | 4 | 11 Jul 2021 |
| 27 | Eleven WondersEleven Wonders2–0 Ebusua DwarfsEbusua Dwarfs | 2 | 2 | 20 Nov 2020 |
| 27 | WAFAWest African Football Academy2–0 Berekum ChelseaBerekum Chelsea | 2 | 2 | 13 Dec 2020 |
| 27 | Liberty ProfessionalsLiberty Professionals2–0 Great OlympicsGreat Olympics | 2 | 2 | 13 Dec 2020 |
| 27 | KarelaKarela2–0 King FaisalKing Faisal | 2 | 2 | 13 Dec 2020 |
| 27 | Aduana StarsAduana Stars2–0 Hearts of OakHearts of Oak | 2 | 2 | 16 Dec 2020 |
| 27 | DreamsDreams2–0 Ebusua DwarfsEbusua Dwarfs | 2 | 2 | 10 Jan 2021 |
| 27 | Asante KotokoAsante Kotoko2–0 Liberty ProfessionalsLiberty Professionals | 2 | 2 | 11 Jan 2021 |
| 27 | Inter AlliesInter Allies0–2 Great OlympicsGreat Olympics | 2 | 2 | 15 Jan 2021 |
| 27 | Hearts of OakHearts of Oak2–0 Eleven WondersEleven Wonders | 2 | 2 | 17 Jan 2021 |