| 1 | Man UtdManchester United6–0 BradfordBradford City | 6 | 6 | 5 Sept 2000 |
| 2 | ChelseaChelsea6–1 CoventryCoventry City | 5 | 7 | 21 Oct 2000 |
| 2 | ArsenalArsenal6–1 LeicesterLeicester City | 5 | 7 | 26 Dec 2000 |
| 2 | Man UtdManchester United6–1 ArsenalArsenal | 5 | 7 | 25 Feb 2001 |
| 2 | LeedsLeeds United6–1 BradfordBradford City | 5 | 7 | 13 May 2001 |
| 2 | ArsenalArsenal5–0 Man CityManchester City | 5 | 5 | 28 Oct 2000 |
| 2 | Man UtdManchester United5–0 SouthamptonSouthampton | 5 | 5 | 28 Oct 2000 |
| 2 | ArsenalArsenal5–0 NewcastleNewcastle United | 5 | 5 | 9 Dec 2000 |
| 2 | Man CityManchester City5–0 EvertonEverton | 5 | 5 | 9 Dec 2000 |
| 2 | West HamWest Ham United5–0 CharltonCharlton Athletic | 5 | 5 | 26 Dec 2000 |
| 11 | CharltonCharlton Athletic4–0 Man CityManchester City | 4 | 4 | 19 Aug 2000 |
| 11 | DerbyDerby County0–4 LiverpoolLiverpool | 4 | 4 | 15 Oct 2000 |
| 11 | LiverpoolLiverpool4–0 ArsenalArsenal | 4 | 4 | 23 Dec 2000 |
| 11 | Man CityManchester City0–4 LeedsLeeds United | 4 | 4 | 13 Jan 2001 |
| 11 | MiddlesbroughMiddlesbrough4–0 DerbyDerby County | 4 | 4 | 13 Jan 2001 |
| 11 | DerbyDerby County0–4 ChelseaChelsea | 4 | 4 | 7 Apr 2001 |
| 11 | Man CityManchester City0–4 ArsenalArsenal | 4 | 4 | 11 Apr 2001 |
| 11 | CharltonCharlton Athletic0–4 LiverpoolLiverpool | 4 | 4 | 19 May 2001 |
| 19 | Aston VillaAston Villa4–1 DerbyDerby County | 3 | 5 | 30 Sept 2000 |
| 19 | West HamWest Ham United4–1 Man CityManchester City | 3 | 5 | 11 Nov 2000 |
| 19 | LiverpoolLiverpool4–1 CoventryCoventry City | 3 | 5 | 12 Nov 2000 |
| 19 | ChelseaChelsea4–1 DerbyDerby County | 3 | 5 | 9 Dec 2000 |
| 19 | BradfordBradford City1–4 SunderlandSunderland | 3 | 5 | 26 Dec 2000 |
| 19 | Man CityManchester City1–4 CharltonCharlton Athletic | 3 | 5 | 30 Dec 2000 |
| 19 | SunderlandSunderland4–1 IpswichIpswich Town | 3 | 5 | 1 Jan 2001 |
| 19 | ChelseaChelsea4–1 IpswichIpswich Town | 3 | 5 | 20 Jan 2001 |
| 19 | ArsenalArsenal4–1 EvertonEverton | 3 | 5 | 21 Apr 2001 |
| 19 | EvertonEverton3–0 CharltonCharlton Athletic | 3 | 3 | 23 Aug 2000 |
| 19 | Man UtdManchester United3–0 SunderlandSunderland | 3 | 3 | 9 Sept 2000 |
| 19 | CoventryCoventry City0–3 West HamWest Ham United | 3 | 3 | 23 Sept 2000 |
| 19 | EvertonEverton0–3 IpswichIpswich Town | 3 | 3 | 30 Sept 2000 |
| 19 | ChelseaChelsea3–0 LiverpoolLiverpool | 3 | 3 | 1 Oct 2000 |
| 19 | LeicesterLeicester City0–3 Man UtdManchester United | 3 | 3 | 14 Oct 2000 |
| 19 | Man UtdManchester United3–0 LeedsLeeds United | 3 | 3 | 21 Oct 2000 |
| 19 | ChelseaChelsea3–0 TottenhamTottenham Hotspur | 3 | 3 | 28 Oct 2000 |
| 19 | MiddlesbroughMiddlesbrough0–3 LeicesterLeicester City | 3 | 3 | 18 Nov 2000 |
| 19 | DerbyDerby County0–3 Man UtdManchester United | 3 | 3 | 25 Nov 2000 |
| 19 | TottenhamTottenham Hotspur3–0 LeicesterLeicester City | 3 | 3 | 25 Nov 2000 |
| 19 | LiverpoolLiverpool3–0 CharltonCharlton Athletic | 3 | 3 | 2 Dec 2000 |
| 19 | ChelseaChelsea3–0 BradfordBradford City | 3 | 3 | 23 Dec 2000 |
| 19 | IpswichIpswich Town3–0 TottenhamTottenham Hotspur | 3 | 3 | 30 Dec 2000 |
| 19 | Aston VillaAston Villa0–3 LiverpoolLiverpool | 3 | 3 | 13 Jan 2001 |
| 19 | BradfordBradford City0–3 Man UtdManchester United | 3 | 3 | 13 Jan 2001 |
| 19 | BradfordBradford City0–3 Aston VillaAston Villa | 3 | 3 | 3 Feb 2001 |
| 19 | LiverpoolLiverpool3–0 West HamWest Ham United | 3 | 3 | 3 Feb 2001 |
| 19 | ArsenalArsenal3–0 West HamWest Ham United | 3 | 3 | 3 Mar 2001 |
| 19 | TottenhamTottenham Hotspur3–0 CoventryCoventry City | 3 | 3 | 17 Mar 2001 |
| 19 | SouthamptonSouthampton0–3 IpswichIpswich Town | 3 | 3 | 2 Apr 2001 |
| 19 | ArsenalArsenal0–3 MiddlesbroughMiddlesbrough | 3 | 3 | 14 Apr 2001 |
| 19 | TottenhamTottenham Hotspur0–3 ChelseaChelsea | 3 | 3 | 17 Apr 2001 |