| 1 | IpswichIpswich Town6–0 DoncasterDoncaster Rovers | 6 | 6 | 28 Sept 2021 |
| 1 | BoltonBolton Wanderers6–0 SunderlandSunderland | 6 | 6 | 29 Jan 2022 |
| 1 | Sheff WedSheffield Wednesday6–0 CambridgeCambridge United | 6 | 6 | 12 Mar 2022 |
| 4 | GillinghamGillingham2–7 OxfordOxford United | 5 | 9 | 29 Jan 2022 |
| 4 | SunderlandSunderland5–0 CheltenhamCheltenham Town | 5 | 5 | 28 Sept 2021 |
| 4 | CheltenhamCheltenham Town0–5 CambridgeCambridge United | 5 | 5 | 7 Dec 2021 |
| 4 | SunderlandSunderland5–0 MorecambeMorecambe | 5 | 5 | 7 Dec 2021 |
| 4 | SunderlandSunderland5–0 Sheff WedSheffield Wednesday | 5 | 5 | 30 Dec 2021 |
| 4 | DoncasterDoncaster Rovers0–5 RotherhamRotherham United | 5 | 5 | 1 Feb 2022 |
| 4 | ShrewsburyShrewsbury Town5–0 MorecambeMorecambe | 5 | 5 | 15 Mar 2022 |
| 4 | PlymouthPlymouth Argyle0–5 MK DonsMilton Keynes Dons | 5 | 5 | 30 Apr 2022 |
| 12 | CambridgeCambridge United1–5 LincolnLincoln City | 4 | 6 | 11 Sept 2021 |
| 12 | OxfordOxford United5–1 AccringtonAccrington Stanley | 4 | 6 | 28 Sept 2021 |
| 12 | RotherhamRotherham United5–1 SunderlandSunderland | 4 | 6 | 30 Oct 2021 |
| 12 | AccringtonAccrington Stanley5–1 FleetwoodFleetwood Town | 4 | 6 | 4 Dec 2021 |
| 12 | RotherhamRotherham United5–1 GillinghamGillingham | 4 | 6 | 7 Dec 2021 |
| 12 | SunderlandSunderland5–1 CambridgeCambridge United | 4 | 6 | 23 Apr 2022 |
| 12 | PortsmouthPortsmouth4–0 SunderlandSunderland | 4 | 4 | 2 Oct 2021 |
| 12 | BoltonBolton Wanderers0–4 WiganWigan Athletic | 4 | 4 | 16 Oct 2021 |
| 12 | Crewe AlexandraCrewe Alexandra0–4 SunderlandSunderland | 4 | 4 | 19 Oct 2021 |
| 12 | PortsmouthPortsmouth0–4 IpswichIpswich Town | 4 | 4 | 19 Oct 2021 |
| 12 | CharltonCharlton Athletic4–0 DoncasterDoncaster Rovers | 4 | 4 | 30 Oct 2021 |
| 12 | BurtonBurton Albion4–0 AccringtonAccrington Stanley | 4 | 4 | 23 Nov 2021 |
| 12 | MorecambeMorecambe0–4 MK DonsMilton Keynes Dons | 4 | 4 | 27 Nov 2021 |
| 12 | GillinghamGillingham0–4 IpswichIpswich Town | 4 | 4 | 8 Jan 2022 |
| 12 | PortsmouthPortsmouth4–0 DoncasterDoncaster Rovers | 4 | 4 | 12 Feb 2022 |
| 12 | BoltonBolton Wanderers4–0 AFC WimbledonAFC Wimbledon | 4 | 4 | 19 Feb 2022 |
| 12 | CharltonCharlton Athletic0–4 OxfordOxford United | 4 | 4 | 19 Feb 2022 |
| 12 | CheltenhamCheltenham Town4–0 DoncasterDoncaster Rovers | 4 | 4 | 5 Mar 2022 |
| 12 | PortsmouthPortsmouth4–0 AccringtonAccrington Stanley | 4 | 4 | 5 Mar 2022 |
| 12 | PlymouthPlymouth Argyle4–0 AccringtonAccrington Stanley | 4 | 4 | 19 Mar 2022 |
| 12 | IpswichIpswich Town4–0 CharltonCharlton Athletic | 4 | 4 | 30 Apr 2022 |
| 33 | IpswichIpswich Town2–5 BoltonBolton Wanderers | 3 | 7 | 11 Sept 2021 |
| 33 | Sheff WedSheffield Wednesday5–2 BurtonBurton Albion | 3 | 7 | 1 Mar 2022 |
| 33 | AccringtonAccrington Stanley1–4 WiganWigan Athletic | 3 | 5 | 18 Sept 2021 |
| 33 | GillinghamGillingham1–4 MK DonsMilton Keynes Dons | 3 | 5 | 18 Sept 2021 |
| 33 | CharltonCharlton Athletic1–4 BoltonBolton Wanderers | 3 | 5 | 28 Sept 2021 |
| 33 | RotherhamRotherham United4–1 PortsmouthPortsmouth | 3 | 5 | 16 Oct 2021 |
| 33 | ShrewsburyShrewsbury Town4–1 CambridgeCambridge United | 3 | 5 | 23 Oct 2021 |
| 33 | Crewe AlexandraCrewe Alexandra1–4 MK DonsMilton Keynes Dons | 3 | 5 | 30 Oct 2021 |
| 33 | WycombeWycombe Wanderers1–4 IpswichIpswich Town | 3 | 5 | 2 Nov 2021 |
| 33 | AccringtonAccrington Stanley1–4 PlymouthPlymouth Argyle | 3 | 5 | 13 Nov 2021 |
| 33 | MK DonsMilton Keynes Dons4–1 CambridgeCambridge United | 3 | 5 | 13 Nov 2021 |
| 33 | BurtonBurton Albion4–1 Crewe AlexandraCrewe Alexandra | 3 | 5 | 1 Jan 2022 |
| 33 | Crewe AlexandraCrewe Alexandra1–4 PlymouthPlymouth Argyle | 3 | 5 | 8 Feb 2022 |
| 33 | AccringtonAccrington Stanley4–1 Crewe AlexandraCrewe Alexandra | 3 | 5 | 12 Feb 2022 |
| 33 | OxfordOxford United4–1 BurtonBurton Albion | 3 | 5 | 5 Mar 2022 |
| 33 | WiganWigan Athletic4–1 MorecambeMorecambe | 3 | 5 | 19 Mar 2022 |
| 33 | Sheff WedSheffield Wednesday4–1 CheltenhamCheltenham Town | 3 | 5 | 26 Mar 2022 |
| 33 | CambridgeCambridge United1–4 WycombeWycombe Wanderers | 3 | 5 | 5 Apr 2022 |